Examination of Clinical Efficacy of Keishibukuryogan on Non-Specific Complaints Associated with Varicose Veins of the Lower Extremity
Identifieur interne : 002B02 ( Main/Exploration ); précédent : 002B01; suivant : 002B03Examination of Clinical Efficacy of Keishibukuryogan on Non-Specific Complaints Associated with Varicose Veins of the Lower Extremity
Auteurs : Shinobu Hayashi [Japon] ; Shintaro Shibutani [Japon] ; Hirotoki Okubo [Japon] ; Tatsuya Shimogawara [Japon] ; Tsuyoshi Ichinose [Japon] ; Yasuhiro Ito [Japon] ; Kouki Mihara [Japon] ; Tomohisa Egawa [Japon] ; Atsushi Nagashima [Japon] ; Hideaki Obara [Japon] ; Yuko Kitagawa [Japon]Source :
- Annals of Vascular Diseases [ 1881-641X ] ; 2014.
Abstract
The subjective symptoms of varicose veins of the lower extremity often include malaise, numbness, coldness, pain, and pruritus of the lower extremity, and relieving these complaints is important in managing the quality of life of patients. We have examined the clinical efficacy of keishibukuryogan, a Kampo prescription for improving oketsu (impaired microcirculation, congestion), on non-specific complaints associated with varicose veins of the lower extremity. Keishibukuryogan was administered to 30 patients with non-specific complaints associated with varicose veins of the lower extremity for 12 weeks, resulting in improvements in the scores of subjective symptoms, severity of varicose veins, and oketsu as well as an increase in skin perfusion pressure. And especially the effect was remarkable in female. In addition, oketsu was shown to be involved in the subjective symptoms associated with varicose veins of the lower extremity, demonstrating efficacy of keishibukuryogan. No adverse drug reaction or abnormal laboratory result was observed in patients receiving keishibukuryogan, and the rate of general improvement and usefulness was 73.3%. It was suggested that keishibukuryogan was useful to improve the symptoms of patients with non-specific complaints associated with varicose veins of the lower extremity especially in female patients. (
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DOI: 10.3400/avd.oa.14-00055
PubMed: 25298828
PubMed Central: 4180688
Affiliations:
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uniqKey="Ito Y" first="Yasuhiro" last="Ito">Yasuhiro Ito</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Mihara, Kouki" sort="Mihara, Kouki" uniqKey="Mihara K" first="Kouki" last="Mihara">Kouki Mihara</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Egawa, Tomohisa" sort="Egawa, Tomohisa" uniqKey="Egawa T" first="Tomohisa" last="Egawa">Tomohisa Egawa</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Nagashima, Atsushi" sort="Nagashima, Atsushi" uniqKey="Nagashima A" first="Atsushi" last="Nagashima">Atsushi Nagashima</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Obara, Hideaki" sort="Obara, Hideaki" uniqKey="Obara H" first="Hideaki" last="Obara">Hideaki Obara</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Surgery, Keio University, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Keio University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Surgery, Keio University, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Keio University, Tokyo</wicri:regionArea><placeName><settlement 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Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Shibutani, Shintaro" sort="Shibutani, Shintaro" uniqKey="Shibutani S" first="Shintaro" last="Shibutani">Shintaro Shibutani</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Okubo, Hirotoki" sort="Okubo, Hirotoki" uniqKey="Okubo H" first="Hirotoki" last="Okubo">Hirotoki Okubo</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Shimogawara, Tatsuya" sort="Shimogawara, Tatsuya" uniqKey="Shimogawara T" first="Tatsuya" last="Shimogawara">Tatsuya Shimogawara</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Ichinose, Tsuyoshi" sort="Ichinose, Tsuyoshi" uniqKey="Ichinose T" first="Tsuyoshi" last="Ichinose">Tsuyoshi Ichinose</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Ito, Yasuhiro" sort="Ito, Yasuhiro" uniqKey="Ito Y" first="Yasuhiro" last="Ito">Yasuhiro Ito</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Mihara, Kouki" sort="Mihara, Kouki" uniqKey="Mihara K" first="Kouki" last="Mihara">Kouki Mihara</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Egawa, Tomohisa" sort="Egawa, Tomohisa" uniqKey="Egawa T" first="Tomohisa" last="Egawa">Tomohisa Egawa</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Nagashima, Atsushi" sort="Nagashima, Atsushi" uniqKey="Nagashima A" first="Atsushi" last="Nagashima">Atsushi Nagashima</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Obara, Hideaki" sort="Obara, Hideaki" uniqKey="Obara H" first="Hideaki" last="Obara">Hideaki Obara</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Surgery, Keio University, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Keio University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Surgery, Keio University, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Keio University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j">Annals of Vascular Diseases</title><idno type="ISSN">1881-641X</idno><idno type="eISSN">1881-6428</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The subjective symptoms of varicose veins of the lower extremity often include malaise, numbness, coldness, pain, and pruritus of the lower extremity, and relieving these complaints is important in managing the quality of life of patients. We have examined the clinical efficacy of keishibukuryogan, a Kampo prescription for improving oketsu (impaired microcirculation, congestion), on non-specific complaints associated with varicose veins of the lower extremity. Keishibukuryogan was administered to 30 patients with non-specific complaints associated with varicose veins of the lower extremity for 12 weeks, resulting in improvements in the scores of subjective symptoms, severity of varicose veins, and oketsu as well as an increase in skin perfusion pressure. And especially the effect was remarkable in female. In addition, oketsu was shown to be involved in the subjective symptoms associated with varicose veins of the lower extremity, demonstrating efficacy of keishibukuryogan. No adverse drug reaction or abnormal laboratory result was observed in patients receiving keishibukuryogan, and the rate of general improvement and usefulness was 73.3%. It was suggested that keishibukuryogan was useful to improve the symptoms of patients with non-specific complaints associated with varicose veins of the lower extremity especially in female patients. (<xref ref-type="fn" rid="fn1">*</xref>English translation of Jpn J Phlebol 2013; 24: 303-310)</p></div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Hayashi, Shinobu" sort="Hayashi, Shinobu" uniqKey="Hayashi S" first="Shinobu" last="Hayashi">Shinobu Hayashi</name></noRegion><name sortKey="Egawa, Tomohisa" sort="Egawa, Tomohisa" uniqKey="Egawa T" first="Tomohisa" last="Egawa">Tomohisa Egawa</name><name sortKey="Ichinose, Tsuyoshi" sort="Ichinose, Tsuyoshi" uniqKey="Ichinose T" first="Tsuyoshi" last="Ichinose">Tsuyoshi Ichinose</name><name sortKey="Ito, Yasuhiro" sort="Ito, Yasuhiro" uniqKey="Ito Y" first="Yasuhiro" last="Ito">Yasuhiro Ito</name><name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name><name sortKey="Mihara, Kouki" sort="Mihara, Kouki" uniqKey="Mihara K" first="Kouki" last="Mihara">Kouki Mihara</name><name sortKey="Nagashima, Atsushi" sort="Nagashima, Atsushi" uniqKey="Nagashima A" first="Atsushi" last="Nagashima">Atsushi Nagashima</name><name sortKey="Obara, Hideaki" sort="Obara, Hideaki" uniqKey="Obara H" first="Hideaki" last="Obara">Hideaki Obara</name><name sortKey="Okubo, Hirotoki" sort="Okubo, Hirotoki" uniqKey="Okubo H" first="Hirotoki" last="Okubo">Hirotoki Okubo</name><name sortKey="Shibutani, Shintaro" sort="Shibutani, Shintaro" uniqKey="Shibutani S" first="Shintaro" last="Shibutani">Shintaro Shibutani</name><name sortKey="Shimogawara, Tatsuya" sort="Shimogawara, Tatsuya" uniqKey="Shimogawara T" first="Tatsuya" last="Shimogawara">Tatsuya Shimogawara</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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